World Federation of Neuro - Oncology Societies magazine

نویسندگان

  • Michael Weller
  • Antonio Chiocca
  • Christine Marosi
چکیده

Purpose of review. To present an overview of the recent findings in pathophysiology and management of epileptic seizures in patients with gliomas. Recent findings. Low-grade gliomas are the most epileptogenic brain tumors. Regarding pathophysiology, the role of peritumoral changes (hypoxia and acidosis, blood–brain barrier disruption, increase or decrease of neurotransmitters and receptors) are of increasing importance. Tumor-associated epilepsy and tumor growth could have some common molecular pathways. Total/subtotal surgical resection (with or without epilepsy surgery) allows seizure control in a high percentage of patients. Radiotherapy and chemotherapy as well have a role. New anti-epileptic drugs are promising, in terms of both efficacy and tolerability. Resistance to anti-epileptic drugs is still a major problem: new insights into pathogenesis are needed to develop strategies to manipulate the pharmacoresistance.

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تاریخ انتشار 2016